{"product_id":"cardiac-safety-of-noncardiac-drugs-practical-guidelines-for-clinical-research-and-drug-development-2005th-edition","title":"Cardiac Safety of Noncardiac Drugs (PDF)","description":"\u003cp\u003e\u003cspan\u003eIt is generally easy to define the efficacy of a new the- peutic agent. However, what is even more difficult and more challenging yet more important is to define its safety when administered to millions of patients with multi-faceted d- eases, co-morbidities, sensitivities and concomitant medi- tions. The commonest cause of new drug discontinuations, cause for disapproval from marketing and removal from the market after approval is a drug's effect on cardiac repolari- tion which is essentially identified by increasing the duration of the QTc interval duration on the standard 12-lead elect- cardiogram (ECG). Cardiac Safety of Noncardiac Drugs: Practical Guide- Joel Morganroth, MD lines for Clinical Research and Drug Development is designed to present the current preclinical, clinical, and re- latory principles to assess the cardiac safety of new drugs based primarily on their effects on the ECG. Practical gu- ance to define cardiac safety at all stages of clinical research and drug development are featured and discussed by inter- tionally recognized experts with academic, industrial, and regulatory experience. Each chapter contains the best ava- able evidence, the author's personal opinions, areas of c- troversy, and future trends. Although some of the areas are highly specialized, this book has been designed for a broad audience ranging from medical and graduate students to cli- cal nurses, clinical trial coordinators, safety officers, data managers, statisticians, regulatory authorities, clinicians, and Ihor Gussak, MD, PhD scientists.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003chr class=\"a-divider-normal bucketDivider\"\u003e\n\u003ch2\u003eProduct details\u003c\/h2\u003e\n\u003cdiv id=\"detailBullets_feature_div\"\u003e\n\u003cul class=\"a-unordered-list a-nostyle a-vertical a-spacing-none detail-bullet-list\"\u003e\n\u003cli\u003e\u003cspan class=\"a-list-item\"\u003e\u003cspan class=\"a-text-bold\"\u003ePublisher ‏ : ‎\u003cspan\u003e \u003c\/span\u003e\u003c\/span\u003e\u003cspan\u003eHumana\u003c\/span\u003e\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan class=\"a-list-item\"\u003e\u003cspan class=\"a-text-bold\"\u003ePublication date ‏ : ‎\u003cspan\u003e \u003c\/span\u003e\u003c\/span\u003e\u003cspan\u003eNovember 4, 2004\u003c\/span\u003e\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan class=\"a-list-item\"\u003e\u003cspan class=\"a-text-bold\"\u003eEdition ‏ : ‎\u003cspan\u003e \u003c\/span\u003e\u003c\/span\u003e\u003cspan\u003e2005th\u003c\/span\u003e\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan class=\"a-list-item\"\u003e\u003cspan class=\"a-text-bold\"\u003eLanguage ‏ : ‎\u003cspan\u003e \u003c\/span\u003e\u003c\/span\u003e\u003cspan\u003eEnglish\u003c\/span\u003e\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan class=\"a-list-item\"\u003e\u003cspan class=\"a-text-bold\"\u003ePdf ‏ : ‎\u003cspan\u003e \u003c\/span\u003e\u003c\/span\u003e\u003cspan\u003e374 pages\u003c\/span\u003e\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan class=\"a-list-item\"\u003e\u003cspan class=\"a-text-bold\"\u003eISBN-10 ‏ : ‎\u003cspan\u003e \u003c\/span\u003e\u003c\/span\u003e\u003cspan\u003e158829515X\u003c\/span\u003e\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan class=\"a-list-item\"\u003e\u003cspan class=\"a-text-bold\"\u003eISBN-13 ‏ : ‎\u003cspan\u003e \u003c\/span\u003e\u003c\/span\u003e\u003cspan\u003e978-1588295156\u003c\/span\u003e\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e","brand":"Humana","offers":[{"title":"Default Title","offer_id":47146506551494,"sku":"Z-0","price":29.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0762\/0893\/1014\/files\/80_Off-2026-09-11T182234.642.png?v=1789146698","url":"https:\/\/cardioebook.com\/products\/cardiac-safety-of-noncardiac-drugs-practical-guidelines-for-clinical-research-and-drug-development-2005th-edition","provider":"Cardioebook","version":"1.0","type":"link"}